Carboxymethylcellulose Calcium (CMC-Ca) Superdisintegrant | High Swelling Capacity for Fast Tablet Disintegration | USP/EP/ChP Compliant

Our Carboxymethylcellulose Calcium (Carmellose Calcium, CMC-Ca) is a high-purity pharmaceutical excipient that functions as an effective disintegrant, binder, and diluent for oral solid dosage forms . It is the calcium salt of carboxymethylcellulose, appearing as a white to off-white hygroscopic powder that is practically insoluble in water but rapidly swells to several times its original volume upon contact with aqueous media . This unique swelling mechanism ensures rapid tablet disintegration and enhanced drug dissolution. Key advantages include: no sodium content (suitable for cardiovascular and sodium-restricted patients) , excellent compressibility, and compatibility with both direct compression and wet granulation processes . Conforms to USP-NF, EP, JP, and ChP pharmacopoeias with CDE registration F20230000328. Typical use level: 0.5-15% w/w.

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Product Detail

Pharmaceutical Grade Carboxymethylcellulose Calcium (Carmellose Calcium, CMC-Ca)

Product Overview

Carboxymethylcellulose Calcium is the calcium salt of a polycarboxymethyl ether of cellulose . It is a multifunctional pharmaceutical excipient widely used as a disintegrant, binder, and diluent in oral solid dosage forms including tablets and capsules . Unlike its sodium counterpart, the calcium salt offers the advantage of sodium-free formulation, making it particularly suitable for cardiovascular and sodium-restricted patient populations .

Product Identity:

Chemical Name: Carboxymethylcellulose Calcium / Carmellose Calcium
CAS Number: 9050-04-8
CDE Registration No.: F20230000328
Pharmacopoeia Compliance: ChP, USP-NF, EP, JP
Synonyms: Calcium carboxymethylcellulose, Calcium CMC, CMC-Ca, Carmellose Calcium
UNII: UTY7PDF93L
Appearance: White to yellowish-white or off-white powder, hygroscopic after drying
Solubility: Practically insoluble in water, acetone, alcohol, and toluene; swells in water to form a suspension

Key Features & Benefits

1. Superior Disintegration Mechanism

Water-insoluble but rapidly swells to several times its original volume upon contact with aqueous media
Creates mechanical pressure that rapidly breaks apart tablets
Ensures fast and complete disintegration for enhanced drug dissolution
Performs well even in hard tablets where other disintegrants may not perform adequately

2. Multifunctional Excipient

Disintegrant: Primary function as tablet disintegrant at 0.5-15% concentrations
Binder: Effective binder in wet granulation processes
Diluent/Filler: Can serve as tablet diluent
Suspension Aid: Used as suspension stabilizer in oral and topical preparations

3. Sodium-Free Advantage

Contains no sodium – ideal for cardiovascular drugs and sodium-restricted patients
Addresses growing regulatory and patient demands for low-sodium formulations
Meets clean-label and health-conscious formulation trends

4. Excellent API Compatibility

Particularly effective for cephalosporin drugs, with demonstrated dissolution improvement properties
Good chelating structure benefits certain API classes
Compatible with a wide range of active ingredients including: Pioglitazone HCl, Aminophylline, Berberine HCl, Milnacipran HCl, Cefixime, Nicorandil, and many others

5. Superior Physical Properties